Jens M Hohlfeld Selected Research

GSK2245035

1/2020

Intranasal GSK2245035, a Toll-like receptor 7 agonist, does not attenuate the allergen-induced asthmatic response in a randomized, double-blind, placebo-controlled experimental medicine study.

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Jens M Hohlfeld Research Topics

Disease

32	Asthma (Bronchial Asthma) 12/2021 - 01/2002
27	Inflammation (Inflammations) 01/2022 - 01/2002
19	Chronic Obstructive Pulmonary Disease (COPD) 04/2022 - 03/2010
8	Pneumonia (Pneumonitis) 10/2020 - 10/2004
6	Hypersensitivity (Allergy) 07/2018 - 06/2010
4	Allergic Rhinitis 12/2021 - 09/2012
4	Seasonal Allergic Rhinitis (Hay Fever) 01/2020 - 10/2011
4	Eosinophilia 01/2018 - 09/2004
4	Reperfusion Injury 09/2005 - 06/2002
3	Emphysema 01/2021 - 06/2008
3	Surfactant Dysfunction 09/2005 - 03/2004
2	Respiratory Tract Diseases (Respiratory Tract Disease) 12/2021 - 01/2012
2	Infections 12/2019 - 06/2010
2	Lung Diseases (Lung Disease) 01/2017 - 01/2012
2	Respiratory Hypersensitivity 05/2015 - 04/2014
2	Airway Obstruction (Choking) 02/2015 - 03/2011
2	Disease Progression 01/2012 - 03/2011
2	Ischemia 08/2007 - 01/2002
2	Hyperplasia 08/2007 - 05/2003
2	Body Weight (Weight, Body) 07/2004 - 05/2003
1	Dyspnea (Shortness of Breath) 04/2022
1	Hypoxia (Hypoxemia) 12/2021
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 12/2021
1	Pulmonary Edema 10/2020
1	Headache (Headaches) 01/2020
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020
1	Hypogonadism (Hypergonadotropic Hypogonadism) 07/2018
1	Myocardial Infarction 01/2018
1	Endometrial Neoplasms (Endometrial Cancer) 01/2018
1	Cough 01/2018

Drug/Important Bio-Agent (IBA)

21	AllergensIBA 12/2021 - 10/2002
11	Biomarkers (Surrogate Marker)IBA 04/2022 - 03/2011
11	Surface-Active Agents (Surfactants)IBA 01/2013 - 01/2002
6	Glycopyrrolate (Glycopyrronium Bromide)FDA LinkGeneric 04/2022 - 01/2018
6	indacaterolIBA 04/2022 - 01/2018
5	GoldIBA 02/2015 - 01/2012
5	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA 04/2014 - 04/2005
4	CytokinesIBA 01/2022 - 01/2005
4	EndotoxinsIBA 10/2021 - 06/2008
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2004
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 09/2005
4	PotassiumIBA 09/2005 - 06/2002
3	Bronchodilator Agents (Bronchodilators)IBA 04/2022 - 01/2018
3	Volatile Organic CompoundsIBA 01/2022 - 09/2011
3	Mometasone Furoate (Nasonex)FDA LinkGeneric 04/2021 - 04/2020
3	Immunoglobulin E (IgE)IBA 01/2021 - 10/2002
3	Pharmaceutical PreparationsIBA 01/2020 - 01/2012
3	Interleukin-6 (Interleukin 6)IBA 01/2019 - 02/2005
3	Catalytic DNA (Deoxyribozyme)IBA 01/2018 - 09/2015
3	Methacholine Chloride (Methacholine)FDA Link 05/2015 - 11/2005
3	Interleukin-5 (Interleukin 5)IBA 05/2015 - 04/2011
3	Pulmonary Surfactants (Pulmonary Surfactant)IBA 01/2013 - 03/2004
2	EnzymesIBA 12/2021 - 06/2010
2	prostaglandin D2 receptorIBA 10/2021 - 02/2014
2	Muscarinic AntagonistsIBA 04/2021 - 01/2016
2	Adrenal Cortex Hormones (Corticosteroids)IBA 04/2021 - 01/2021
2	Acetates (Acetic Acid Esters)FDA Link 04/2021 - 01/2021
2	RNA (Ribonucleic Acid)IBA 01/2021 - 12/2019
2	LipopolysaccharidesIBA 10/2020 - 01/2012
2	Arginine (L-Arginine)FDA Link 01/2020 - 06/2010
2	Therapeutic UsesIBA 01/2017 - 03/2009
2	Messenger RNA (mRNA)IBA 09/2015 - 03/2014
2	von Willebrand FactorIBA 01/2015 - 03/2014
2	OzoneIBA 09/2011 - 04/2011
2	poractant alfa (Curosurf)FDA Link 01/2009 - 03/2004
2	salicylhydroxamic acid (SHAM)IBA 01/2006 - 06/2003
2	Dextrans (Dextran)FDA Link 09/2005 - 01/2005
2	CelsiorIBA 07/2004 - 06/2002
1	AldehydesIBA 01/2022
1	Angiotensin-Converting Enzyme 2IBA 12/2021
1	Prostaglandin D2IBA 10/2021
1	Interleukin-17 (Interleukin 17)IBA 01/2021
1	Thymic Stromal LymphopoietinIBA 01/2021
1	Monoclonal AntibodiesIBA 01/2021
1	16S Ribosomal RNAIBA 01/2021
1	tiotropium-olodaterolIBA 12/2020
1	Fluticasone-Salmeterol Drug Combination (Advair)FDA Link 12/2020
1	CationsIBA 10/2020
1	GSK2798745IBA 10/2020
1	Salmeterol Xinafoate (Serevent)FDA Link 04/2020
1	Fluticasone (Cutivate)FDA LinkGeneric 04/2020
1	GSK2245035IBA 01/2020
1	Amino Acids FDA Link 01/2020
1	Carnitine (L-Carnitine)FDA LinkGeneric 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Glutamine (L-Glutamine)FDA Link 01/2020
1	LipidsIBA 01/2020
1	NitrogenIBA 01/2020
1	Glutamic Acid (Glutamate)FDA Link 01/2020
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2019
1	GadoliniumIBA 01/2019
1	Testosterone (Sustanon)FDA Link 07/2018
1	perflutren (octafluoropropane)FDA Link 01/2018
1	Iron-Dextran Complex (InFed)FDA Link 01/2018
1	FluorineIBA 01/2018
1	Tiotropium Bromide (Spiriva)FDA Link 01/2016
1	SteroidsIBA 10/2015

Therapy/Procedure

6	Therapeutics 04/2022 - 01/2009
3	Lung Transplantation 09/2005 - 01/2002
1	Aftercare (After-Treatment) 01/2020